![]() Whatever the reason, the best way to deal with this is to get all that adenosine metabolized. My "theory" (completely uneducated, uninformed guess) is that either caffeine is similar enough to adenosine that sometimes it doesn't just block the receptors but can actually trigger them, or else adenosine levels are built up so high that the caffeine just pisses them off and creates the neurochemical version of a riot. Whatever is happening, the brain seems to be interpreting it as a flood of adenosine. You can buy pills such as No Doz, Revive, Vivarin, and many others online or at your local pharmacy, and theyre tiny enough to tuck. I've experienced what you're talking about, and it's not just that the caffeine fails to wake me up: It actually makes me drowsy-borderline intoxicated-in a very similar way to diphenhydramine or doxylamine which is what is in cough syrups. Caffeine pills are easily accessible, portable, and cheap. That doesn't always seem to be what happens though. Caffeine is similar enough in structure that it binds to the adenosine receptors in the brain, thus blocking adenosine from doing its thing. ![]() Adenosine levels have a big impact on how sleepy or alert we feel. It builds up while we're awake, makes us sleepy, and then metabolizes during sleep. Adenosine is basically a waste product of biological energy production. Caffeine pills are a common supplement made using caffeine from either natural or synthetic sources. We actually aren't 100% positive how caffeine works, but best indications point to the blocking of adenosine as the most likely mechanism.
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